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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
MED12
All Species:
16.97
Human Site:
S652
Identified Species:
41.48
UniProt:
Q93074
Number Species:
9
Phosphosite Substitution
Charge Score:
0
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
Q93074
NP_005111.2
2177
243081
S652
E
H
K
E
A
E
G
S
S
S
S
K
L
E
D
Chimpanzee
Pan troglodytes
Q7YQK8
2027
226320
N598
E
S
C
S
H
E
C
N
Q
R
L
V
V
L
F
Rhesus Macaque
Macaca mulatta
XP_001088424
2180
243301
S652
E
H
K
E
A
E
G
S
S
S
S
K
L
E
D
Dog
Lupus familis
XP_848775
2179
243307
S653
E
R
K
E
T
E
G
S
S
S
S
K
L
E
D
Cat
Felis silvestris
Mouse
Mus musculus
A2AGH6
2190
244543
S653
E
R
K
E
A
E
G
S
S
S
S
K
L
E
D
Rat
Rattus norvegicus
XP_002727625
2181
243366
S653
E
R
K
E
A
E
G
S
S
S
S
K
L
E
D
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
Chicken
Gallus gallus
XP_422838
1480
164510
V134
A
F
P
T
L
E
T
V
F
T
K
L
Q
Q
L
Frog
Xenopus laevis
Zebra Danio
Brachydanio rerio
Q2QCI8
2173
243973
G657
E
R
K
D
Q
D
A
G
S
S
V
K
M
E
D
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
Q9VW47
2531
279480
P751
A
T
K
T
S
P
P
P
P
A
P
P
P
T
T
Honey Bee
Apis mellifera
XP_392792
2190
244564
L648
E
P
I
D
E
E
C
L
F
P
G
I
E
T
K
Nematode Worm
Caenorhab. elegans
Sea Urchin
Strong. purpuratus
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Baker's Yeast
Sacchar. cerevisiae
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
92.8
99.7
97.8
N.A.
96.7
96.3
N.A.
N.A.
35.4
N.A.
74.7
N.A.
34.7
42.4
N.A.
N.A.
Protein Similarity:
100
92.9
99.7
98.6
N.A.
97.9
97.8
N.A.
N.A.
45.2
N.A.
83.8
N.A.
49.3
58.3
N.A.
N.A.
P-Site Identity:
100
13.3
100
86.6
N.A.
93.3
93.3
N.A.
N.A.
6.6
N.A.
46.6
N.A.
6.6
13.3
N.A.
N.A.
P-Site Similarity:
100
26.6
100
86.6
N.A.
93.3
93.3
N.A.
N.A.
20
N.A.
66.6
N.A.
20
20
N.A.
N.A.
Percent
Protein Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
20
0
0
0
40
0
10
0
0
10
0
0
0
0
0
% A
% Cys:
0
0
10
0
0
0
20
0
0
0
0
0
0
0
0
% C
% Asp:
0
0
0
20
0
10
0
0
0
0
0
0
0
0
60
% D
% Glu:
80
0
0
50
10
80
0
0
0
0
0
0
10
60
0
% E
% Phe:
0
10
0
0
0
0
0
0
20
0
0
0
0
0
10
% F
% Gly:
0
0
0
0
0
0
50
10
0
0
10
0
0
0
0
% G
% His:
0
20
0
0
10
0
0
0
0
0
0
0
0
0
0
% H
% Ile:
0
0
10
0
0
0
0
0
0
0
0
10
0
0
0
% I
% Lys:
0
0
70
0
0
0
0
0
0
0
10
60
0
0
10
% K
% Leu:
0
0
0
0
10
0
0
10
0
0
10
10
50
10
10
% L
% Met:
0
0
0
0
0
0
0
0
0
0
0
0
10
0
0
% M
% Asn:
0
0
0
0
0
0
0
10
0
0
0
0
0
0
0
% N
% Pro:
0
10
10
0
0
10
10
10
10
10
10
10
10
0
0
% P
% Gln:
0
0
0
0
10
0
0
0
10
0
0
0
10
10
0
% Q
% Arg:
0
40
0
0
0
0
0
0
0
10
0
0
0
0
0
% R
% Ser:
0
10
0
10
10
0
0
50
60
60
50
0
0
0
0
% S
% Thr:
0
10
0
20
10
0
10
0
0
10
0
0
0
20
10
% T
% Val:
0
0
0
0
0
0
0
10
0
0
10
10
10
0
0
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% W
% Tyr:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _